In patients with non-ischemic cardiomyopathy, cardiac KLF15 gene expression was reduced by 50% compared to control patients [12], and in those undergoing a left ventricular assist device implantation and explantation as a bridge to transplantation, KLF15 was reduced in the failing heart compared to controls, with significant recovery of KLF15 expression after mechanical unloading [30]. The gene discussed is KLF15; the disease is ischemic cardiomyopathy.