The low-activity chaperones HspB2, HspB6 and HspB8 specifically associate with fibrillar amyloid β rather than non-aggregated forms in a hereditary cerebral amyloid angiopathy caused by the rapidly aggregating amyloid β1–40 carrying the “Dutch” mutation 22Glu → Gln [58]. Here, HSPB6 is linked to cerebral amyloid angiopathy.