Although occurring less frequently than in endometrial cancer, c-terminal activating CCND1 mutations were also identified in other cancer types, such as gastrointestinal adenocarcinoma (esophageal, stomach, colorectal, ampula of vater), squamous cell carcinoma (head & neck, lung, skin), urothelial carcinoma, cutaneous melanoma, angiosarcoma, ovarian carcinoma (low grade serous and endometrioid types) and uterine epithelioid leiomyosarcoma (Table 5). The gene discussed is CCND1; the disease is cutaneous melanoma.