The overall rate of CCND1 mutations was 1.1% in colorectal carcinoma and cutaneous melanoma (23 of 2,067 cases and 8 of 708 cases respectively) with a smaller percentage of mutations occurring specifically in the c-terminal region of cyclin D1 (0.7%, 5 of 708 cases in cutaneous melanoma and 0.4%, 9 of 2067 in colorectal carcinoma). This evidence concerns the gene CCND1 and colorectal carcinoma.