Alterations of cyclin D1 resulting in nuclear protein expression is thought to promote tumorigenesis in various types of cancers[1][2], often as a result of CCND1 gene amplification, such as in breast, lung, bladder carcinomas [3][4], or as a result of CCND1 translocation in mantle cell lymphoma [5]. The gene discussed is CCND1; the disease is urinary bladder carcinoma.