In mantle cell lymphoma and multiple myeloma, the majority of CCND1 mutations occurred within the amino terminal domain of cyclin D1 (S2 Table and Fig 1B), while in endometrial adenocarcinomas, and less frequently in colorectal carcinoma and melanoma, CCND1 mutations centered on the carboxy terminal domain (Fig 1C and 1D and S1 Fig). The gene discussed is CCND1; the disease is colorectal carcinoma.