A recent meta-analysis detected a considerable decrease in theongoing pregnancy rate of patients prescribed pretreatment with OCP (Griesinger et al., 2010).Comparisons between a pituitary down-regulation protocol and a GnRH antagonistprotocol at the beginning of ovarian stimulation found that women with PCOS inparticular had higher serum gonadotropin and E2 levels. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.