Univariate models showed a protective association of anti-α-Gal IgM (OR [CI] 0.43 [0.26; 0.68], p = 0.001), IgG3 (0.02 [0; 0.18], p < 0.001) and IgG4 (0.02 [0; 0.2], p = 0.001) with clinical malaria (Table 5). This evidence concerns the gene IGHG3 and malaria.