HDAC10 and neuroblastoma: In conclusion, we demonstrate that HDAC10 inhibition sensitizes chemoresistant neuroblastoma cell lines by (i) increasing intracellular doxorubicin levels via inhibition of lysosomal exocytosis, (ii) by inhibiting pro-survival features of lysosomal exocytosis under stress conditions, and (iii) by inducing DSBs, possibly via interference with DSB repair.