Western blot analysis of LAMP-2 expression after knockdown of HDAC6 or HDAC10 in highly chemoresistant MYCN amplified, TP53 mutated SK-N-BE(2)-C neuroblastoma cells (hereafter referred to as BE(2)-C) revealed that both knockdown of HDAC6 and HDAC10 resulted in LAMP-2 accumulation, albeit to a significantly greater extent after HDAC10 knockdown (Fig. 1a). The gene discussed is TP53; the disease is neuroblastoma.