Moreover, in light of recent reports showing that HDAC10 is involved in DNA double-strand break (DSB) repair and given the fact that doxorubicin induces DSBs by so-called topoisomerase II poisoning33,46,47, we assumed that this link to DNA damage might further affect doxorubicin sensitivity of neuroblastoma cells. Here, HDAC10 is linked to neuroblastoma.