In MC-38 tumor models, we demonstrated that TgMGLL stimulated the expression of proinflammatory cytokines (IL-1β and TNFα) and reduced the levels of anti-inflammatory cytokines (IL-10, Arg-1, and TGFβ) in a CB2-dependent manner in TAMs (Supplementary Fig. 4f). Here, IL1B is linked to neoplasm.