CRP and Erythema: The disease develops in humans approximately 2–8 days after being bitten by a tick carrying the pathogen.2 The main characteristic clinical features of JSF are high fever, erythema with no pain or itching, and tick bite eschar.1,2 Erythema also appears on the extremities and trunk, as well as on the palms and soles of the feet.2 The main laboratory findings among JSF cases include leukocytosis or leukopenia, thrombocytopenia, elevated C-reactive protein (CRP), and elevated liver enzymes.2,3