Of note, a depressed PGC1α transcriptional network is a feature of heart failure induced by pressure overload (Garnier et al., 2003) or myocardial infarction, and it correlates with a reduced mitochondrial respiratory capacity, even when mitochondrial mass is not decreased, which is observed in human hypertrophic myocardium and ischaemic‐induced failing heart (Pisano et al., 2016) (Figure 2). Here, PPARGC1A is linked to myocardial infarction.