For example, different mouse models with global or cardiac‐specific deletion of PGC1α, PPAR and ERR have been generated, resulting in the development of cardiomyopathy, although murine models with constitutive overexpression of PGC1 and PPAR are associated with increased mitochondrial biogenesis, which also leads to cardiomyopathy and heart failure (Rowe et al., 2010). The gene discussed is PPARGC1A; the disease is heart failure.