PPARGC1A and heart failure: Of note, a depressed PGC1α transcriptional network is a feature of heart failure induced by pressure overload (Garnier et al., 2003) or myocardial infarction, and it correlates with a reduced mitochondrial respiratory capacity, even when mitochondrial mass is not decreased, which is observed in human hypertrophic myocardium and ischaemic‐induced failing heart (Pisano et al., 2016) (Figure 2).