We found that LBP could maintain high levels of T cells in systemic and local tissues, prevent the increase of Tregs while promoting infiltration of CD8+ T cells in tumor tissue, inhibit the production of TGF-β1 and IL-10 in serum, decrease the exhaustion phenotype of T cells, and maintain cytotoxicity of lymphocytes. The gene discussed is TGFB1; the disease is neoplasm.