IGHE and chronic rhinosinusitis without nasal polyps: Consistently, it has been shown that the polypoid tissue contains increased amounts of the eosinophil-specific chemokine, C-C motif ligand-11, eosinophil cationic protein, IL-5, total IgE, and SEA- and SEB-specific IgE, relative to controls with CRSsNP [7].