EGF and neoplasm: In particular, CAFs differentiation can be induced by tumour cell-derived transforming growth factor β (TGF-β), epidermal growth factor (EGF), PDGFα, PDGFβ, basic fibroblast growth factor (bFGF, also known as FGF2), interleukin 6 (IL-6), and interleukin 1β (IL-1β) [11, 18].