SOD2 and cancer: For the metabolic crosstalk between CAFs and cancer cells, the HIF-1-driven transcriptional activity is important and can also be mediated by activation of sirtuin1 (SIRT1) signalling that ensures deacetylation of peroxisome proliferator activated receptor gamma coactivator 1α (PGC1-α) or by mitochondrial deacetylase SIRT3 downregulation that increases the level of inactive superoxide dismutase 2 (SOD2) acetylated [47, 54].