Increased Bcl-2 expression has been identified as a reason for resistance to 5-fluorouracil in other GI tumors, too, but the posttranscriptional regulation of mRNA coding for Bcl-2 is under the control of different miRNAs; e.g., in gastric cancer diminished expression of miR-204 is the reason (281). The gene discussed is BCL2; the disease is gastric cancer.