In liver cancer, upregulation of lncRNA HULC activates autophagy by increasing the expression of ubiquitin-specific peptidase 22 (USP22) which in turn prevents the ubiquitin-mediated degradation of silent information regulator 1 (SIRT1) by removing the conjugated polyubiquitin chains from SIRT1 (51). The gene discussed is USP22; the disease is liver cancer.