The notion that functional NOX2 may promote the expansion of NOX2+ leukemia is supported by results showing that NOX2 knockdown in OCI-AML3 cells prolongs the survival of xenografted mice in an AML model (13) and that genetic ablation of NOX2 from hematopoietic cells reduces the in vivo expansion of murine BCR-ABL1+ leukemic cells in a CML model (50). Here, RUNX2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.