The leading-edge analysis identified 15 genes that contribute to the enrichment of these pathways (ARHGEF9, GABRA1, GABRA2, GABRA5, GABRA6, GABRB2, GABRB3, GABRG2, GABRG3, GABRR1, GABRR2, GLRA1, GLRA2, GLRA3, GLRB) implicating chloride currents in the development of form-deprivation myopia (Zhang et al., 2011). The gene discussed is ARHGEF9; the disease is myopia.