In unstressed cells, SUV39H1 is deubiquitinated and protected from MDM2-mediated degradation by HAUSP, promoting the repression of p53-responsive gene transcription.84 Stabilization of histone demethylase PHF8 by HAUSP modulates both epigenetics and DNA damage repair under genotoxic stress, promoting breast cancer.45 This evidence concerns the gene TP53 and breast carcinoma.