NPM1 and chronic myelogenous leukemia, BCR-ABL1 positive: In NPM1-mutated acute myeloid leukemia (AML), mutated NPM1 inhibits HAUSP-mediated deubiquitination of PTEN for retention in the cytoplasm and subsequent degradation.46 In chronic myeloid leukemia (CML) harboring the BCR-ABL mutation, BCR-ABL promotes HAUSP-mediated deubiquitination of nuclear PTEN to drive it out of the nucleus.