NFκB can be directly deubiquitinated by HAUSP87 or can be indirectly regulated by deubiquitination of its upstream factors, such as TRAF6,24 NEMO (IKK-γ)24,91 (HSCARG interacts with NEMO to suppress its polyubiquitination by recruiting HAUSP91), NIMA (Never In Mitosis Gene A)-related kinase 2 (Nek2), a centrosomal serine/threonine kinase (HAUSP stabilizes Nek2 leading to activation of NFκB pathway in multiple myeloma).92 Here, NFKB1 is linked to plasma cell myeloma.