In unstressed cells, SUV39H1 is deubiquitinated and protected from MDM2-mediated degradation by HAUSP, promoting the repression of p53-responsive gene transcription.84 Stabilization of histone demethylase PHF8 by HAUSP modulates both epigenetics and DNA damage repair under genotoxic stress, promoting breast cancer.45 The gene discussed is USP7; the disease is breast carcinoma.