In the context of cancer, no effective mutations in the HAUSP gene have been identified to date, suggesting that its loss or gain of function may not be favorable for tumor growth.35,36 To further support this fact, in a mouse model, HAUSP knockout in vivo stabilizes p53, leading to growth arrest and embryonic lethality within 6.5–7.5 days. This evidence concerns the gene USP7 and neoplasm.