The role of IL-6-induced or constitutively activated STAT3 in negatively regulating HAUSP protein and mRNA expression in colon cancer has also been reported.101 HAUSP expression is enhanced by FoxO6, which inhibits proliferation of lung carcinoma.100 Although PHF8 is stabilized by HAUSP, it can subsequently transactivate HAUSP.45 Another set of endogenous cellular regulators include microRNAs (miRs), and miR-205 negatively regulates HAUSP by targeting its 3‘-UTR in hepatocellular carcinoma. This evidence concerns the gene USP7 and hepatocellular carcinoma.