Thus, pulmonary PGI2 affords potent antiplatelet and vasoprotective activity, activating also CD141-dependent anticoagulant mechanisms which might constitute an important compensatory mechanism in diabetes offsetting inflammatory and thrombotic processes in diabetes involving also detrimental COX-2-derived metabolites contributing to endothelial dysfunction in diabetes [49, 50, 52] . This evidence concerns the gene THBD and endothelial dysfunction.