NRP1 and systemic sclerosis: Further studies on late-outgrowth EPC-derived endothelial cells from SSc patients have revealed that when compared with patient mature dermal microvascular endothelial cells, these EPC-derived cells may already present or not alterations in the expression of key regulators of vascular integrity and angiogenesis, such as epidermal growth factor-like domain 7 (EGFL7) (76),the key VEGF co-receptor neuropilin-1 (NRP-1), and Fli1 transcription factor (77).