However, among cytotoxic lymphocytes, natural killer (NK) cells may be more suitable as therapeutic effectors against highly heterogeneous tumors such as GBM, since unlike T and B lymphocytes, they do not possess rearranged V(D)J receptors and are not restricted by major histocompatibility complex (MHC)-bound antigen presentation. The gene discussed is HLA-C; the disease is glioblastoma.