AR and posterior cortical atrophy: Several studies have attempted to identify AR-regulated genes by focusing on genome-wide AR-binding sites on cell lines and clinical samples, or by examining temporal regulation of androgen stimulation in one or more PCa cell lines such as LNCaP (harbors an LBD mutation of AR), VCaP (contains AR gene amplification) or C4-2B (a CRPC cell line) (66, 79–85).