SLC2A9 and Renal insufficiency: Indeed, genetic analysis of the hyperuricosuric Dalmatian dog breed revealed the presence of the C188F mutation (corresponding to residue C210 in humans) in the canine SLC2A9 gene (Bannasch et al., 2008) and Glut9 knockout mice display high fractional excretion of urate, leading to hyperuricosuria, tubular obstruction and renal failure (Preitner et al., 2009).