First, human mutations of SLC2A9 lead to Renal Hypouricemia type 2 (RHUC-2, OMIM #612067), a monogenic disease characterized by very low SUA (decreased by 70 to 90%), high fractional excretion of urate and occasional exercise-induced acute renal failure (Polasek et al., 2010). The gene discussed is SLC2A9; the disease is acute kidney injury.