Of these DE mRNAs and miRNAs, we deemed five genes (NDUFS1, COX4I1, SDHC, CDC42, and MAPK8) and three miRNAs (miR-126-5p, miR-29a-3p, and miR-19b-3p) worth exploring due to their relationship with the NAFLD pathway or the biological process of mitochondrial function. Here, SDHC is linked to metabolic dysfunction-associated steatotic liver disease.