APOE and Alzheimer disease: Therefore, the aims of the present study are the following: first, to evaluate whether cortical amyloid deposition is related to blood biomarkers and clinical manifestation of dementia; second, to elucidate the relation between amyloid deposition and cortical atrophy in individual brain regions; and third, to explore the effects of ApoE4 carrier status on cortical amyloid deposition in healthy control subjects, subjects with amnesic MCI (aMCI) and subjects with AD.