Therefore, the aims of the present study are the following: first, to evaluate whether cortical amyloid deposition is related to blood biomarkers and clinical manifestation of dementia; second, to elucidate the relation between amyloid deposition and cortical atrophy in individual brain regions; and third, to explore the effects of ApoE4 carrier status on cortical amyloid deposition in healthy control subjects, subjects with amnesic MCI (aMCI) and subjects with AD. This evidence concerns the gene APOE and amyloidosis.