Downregulated genes were significantly involved in KEGG pathways related to autoimmune thyroid disease, natural killer cell-mediated cytotoxicity, cytokine-cytokine receptor interactions, chemokine signalling pathways, B-cell receptor signalling pathways, intestinal immune networks for IgA production, systemic lupus erythematosus, viral myocarditis, asthma, and type I diabetes mellitus. The gene discussed is CD79A; the disease is autoimmune thyroid disease.