However, the expression of Ccr3 significantly increased in the perigonadal WAT on a HFD (Fig. 4f), as well as the frequency and number of eosinophils (Figs 4h and S7a), implying the preferential infiltration of eosinophils into adipose tissue with obesity. Here, CCR3 is linked to obesity due to melanocortin 4 receptor deficiency.