CD8A and infection: Similarly, CEACAM1-deficient P14 CD8+ T cells exhibited limited IFN-γ production after in vitro restimulation with GP33 peptide (Fig. 3e), and this reduction in CD8+ T cell expansion and IFN-γ production was associated with enhanced viral titers in spleen, lung, liver, and serum at day 8 after infection (Fig. 3f).