FLT3 and acute myeloid leukemia: Already in the first publication on acquired UPDs in AML [1], it was reported that a case with UPD19q12-qter harbored a homozygous mutation in the CEBPA gene in 19q13.11 and, soon afterward, AML cases with sUPDs of 11p, 13q, and 21q were shown to carry homozygous mutations of the WT1, FLT3, and RUNX1 genes [3].