Moreover, the overlap between HD signatures and the transcriptional consequences of these epigenetic perturbations was also confirmed in other HD datasets (Supplementary Fig. S3) and, most importantly, in the caudate nucleus profile from patients, mainly for the top DRGs from the Ezh1/Ezh2 KO (P < 0.00001 χ2 = 201.6, d.f. = 19, Fig. 4d) and the CBP cKO (P < 0.00001 χ2 = 96.9, d.f. = 19, Fig. 4e). The gene discussed is CREBBP; the disease is Huntington disease.