A recent study by Castro et al. 42 reported that matrix metalloproteinase 2 (MMP2) may interact with calponin-1 in aortic vascular smooth muscle cells and that MMP2 mediated proteolysis of calponin-1 during endotoxemia may contribute to LPS-induced hypocontractility. Here, CNN1 is linked to serum lipopolysaccharide activity.