GLIPR1 and neoplasm: Among the downregulated proteins, we found two proteins with tumor suppression function (Fig. 3D), Glioma Pathogenesis-Related Protein 1 (GLIPR1, −1.7-fold; P≤0.01) and Smed-MMPB (−1.8-fold; P≤0.05); interestingly, MMPB is one of the four proteins that were downregulated in Cd-exposed regenerating animals (−1.6-fold; P≤0.05).