Myeloid-related protein 8 (MRP8), also known as S100A8, is an intracellular calcium-binding protein, and its expression as a heterodimer complex with other S100 proteins (S100A8/S100A9) has been reported to be a clinically useful biomarker in the sera (Cayatte et al., 2012) and intestinal tissues (Foell et al., 2008) of IBD patients. This evidence concerns the gene S100A8 and inflammatory bowel disease.