Over 6 weeks of culture, the model shows a progressive increase in collagen content and mature collagen cross-links in association with expression of all LOX/LOXL family members (Figure 5A–D); histochemical staining of the resultant tissue construct showed fibrillar collagen deposition (Figure 5E) similar to that seen in fibroblastic foci, the site of active fibrogenesis in IPF (Figure 5F) (Jones et al., 2016). Here, LOXL3 is linked to idiopathic pulmonary fibrosis.