The current study established acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and chronic MPTP/probenecid (MPTP/p)-induced PD model with C57BL/6J mice in order to determine the role that NLRP3 inflammasomes play in the liver and the brain involved during the pathogenesis of PD. This evidence concerns the gene NLRP3 and Parkinson disease.