MPTP is a commonly used toxin when establishing the PD model for research in vivo, so we prepared an acute MPTP and a chronic MPTP/p model in order to detect the changes in the expressions of NLRP1, NLRP2, NLRP3, NLRC4, and AIM2 in the mouse midbrain. The gene discussed is NLRP1; the disease is Parkinson disease.