TGFB1 and neoplasm: Notwithstanding the complexities of TGF-β pathway modulation our study shows that in selected carcinomas an inhibition of αVβ6/TGF-β signaling axis alters the tumor stroma towards an alteration of the collagen network structure that previously has been shown to be associated with improved drug efficacy; the present study could open new venues in the research to improve chemotherapeutic efficacy.