ERBB2 and neoplasm: Designed Ankyrin repeat proteins (DARPin) domains allow the generation of oncolytic viruses with double specificity, simultaneously targeting HER2 and EpCAM54 (a cancer stem cell marker), handling intratumoural variation of antigen expression and targeting simultaneously CSCs and the tumour mass, showing oncolytic potential in a disseminated OC xenograft model in mice, furthermore, showing the superior efficacy of bispecific over monospecific viruses [106].