Its inhibition by siRNA transfection reduced the cell invasion potential, migration and intercellular adhesion, and induced cell anoikis, a form of apoptosis in cells detached from the surrounding extracellular matrix (OC cells must acquire anoikis resistance to survive in ascites), maybe through a change of PTEN/AKT and beta 1 integrin/AKT pathway functions (since Beta 1 integrin, MMP-9 and phosphor-AKT protein levels were significantly down-regulated and PTEN upregulated) in A2780 cancer cells [67]. The gene discussed is ITGB1; the disease is cancer.