The observed genotype frequencies of Apa-1 (rs7975232), Bsm-1 (rs1544410), Fok-1 (rs2228570), and Taq-1 (rs731236) polymorphisms in the VDR gene were studied in 110 alcohol-abuse controls with diagnosed alcohol-abuse and 129 patients with acute pancreatitis. The gene discussed is VDR; the disease is acute pancreatitis.