TGM2 and osteoporosis: Agardh et al. [49] reported a study of 6480 women aged 50–64 years old (mean age 56 years) in whom both BMD (by wrist dual X-ray absorptiometry) and anti-tTG measurements were taken; they found that those with elevated tTG (≥17 IU/mL), representing approximately 0.9% of the sample, were significantly more likely to have osteoporosis (13.4% vs. 6.5%, p = 0.008) and fracture risk (32% vs. 19%, p = 0.009).