In a dietary intervention study, a specific synbiotic mixture of prebiotic short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS), and a probiotic strain Bifidobacterium breve M-16V resulted in significant improvement in IgE-associated AD severity in infants (19), leading to the prevention of asthma-like symptoms and asthma medication use at the 1-year follow-up (20). Here, IGHE is linked to asthma.