These hub proteins were mainly involved in AMPK signaling pathway (CREB1, FOXO3, IRS1 and PPARG), Neurotrophin signaling pathway (BCL2, FOXO3, IRS1 and SH2B1), PI3K-Akt signaling pathway (BCL2, CREB1, FOXO3 and IRS1), Circadian rhythm (BTRC and CREB1), T2D (IRS1 and KCNJ11), and several cancer associated pathways. Here, SH2B1 is linked to cancer.