STAT3 and obesity due to melanocortin 4 receptor deficiency: In this study, we identified some obesity GWAS SNPs that were located at the binding sites of adipogenic differentiation and lipid metabolism related transcription factors CEBPB, TCF7L2, STAT3, SPI1, GATA2, CREB1 and MEF2C, and were eQTLs of obesity or lipid metabolism associated genes, such as ADCY3, CTSS, KCTD15, MTCH2 and SPI1. Genetic and epigenetic studies have demonstrated that ADCY3 is involved in the pathogenesis of obesity [11].