A recent large genome-wide association study of FECD added an additional 3 genes to the candidate list (KANK4, LAMC1 and LINC00970/ATP1B1) and re-confirmed the strongest genetic signal for FECD in a predominantly caucasian U.S. population in the transcription factor 4 (TCF4) gene on chromosome 18 [10]. This evidence concerns the gene KANK4 and Fuchs endothelial corneal dystrophy.