PCNA and cancer: Moreover, Choi and colleagues reported that açaí treatment down-regulated myeloperoxidase (MPO) and proinflammatory cytokines (TNF-α, IL-1β and IL-6), inhibited cyclooxygenase 2 (COX-2), PCNA and Bcl-2, and increased Bad and cleaved caspase-3 expression in an experimental model of cancer colon [43].