ABCG2 and Familial prostate cancer: Breast and prostate cancer cell lines were more sensitive to MβCD-induced cell death than their normal counterparts.[120] In particular, MβCD treatment induced a substantial decrease (40%) in activity of breast cancer resistance protein (BCRP/),[121] which transports PS and PC analogues.[43] In subsequent functional studies, MβCD inhibited spheroid migration and invasion of MDA-MB-241 and ZR751 breast cancer cells [122] and also endocytosis [123] and migration [72] of MCF7 breast cancer cells.