In PBCS, the top gene in both muGWAS and ssGWAS was DOCK881704, followed by the nuclear receptor corepressor NCOR29612, which has been implicated in tamoxifen resistance in breast cancer.[39, 40] CACNA1C775 (3rd) is highly up-regulated in breast cancer.[41] The multiple epidermal GF-like domains protein 11 (MEGF1184465, 4th), like MEGF1084466 an ortholog of C. elegans Ced-1 and the Drosophila draper, had been implicated in colorectal cancer. The gene discussed is IFT122; the disease is colorectal cancer.