RAB27A and melanoma: Tumor-derived exosomes, 30–150 nm sized extracellular vesicles formed by dysregulated EEC, are critical mediators of intercellular communication between tumor cells and recipient stromal cells in both local and distant microenvironments.[94, 95] Several Rab proteins (Rab2b/5a/9a/27a/27b) are known to function in the selective packaging and production of exosomes in tumor cells (Fig 3, bottom left).[96] Rab27a knockdown in highly metastatic melanoma cells significantly decreased exosome production, primary tumor growth, and metastasis,[97] confirming the role of EEC in generating exosomes.