THBS1 and cancer: Annexins are frequently overexpressed in breast, liver, prostate, and pancreatic cancers and participate in multiple functions in cancer, including angiogenesis, tumor migration and invasion.[106] In breast cancer, exosomal annexin A2 promotes angiogenesis and vascularization via tissue plasminogen activator (tPA).[91] In pancreatic cancer, exosomal annexin A6 from cancer-associated fibroblasts contributes to tumor cell survival and invasion through annexin A6 / LDL receptor-related protein 1/thrombospondin 1 complex formation.[105]