TNF and disseminated peritoneal leiomyomatosis: However, a panel of profibrogenesis (Collagen α1(I), Collagen α1(IV), PAI-1, TGFβ1, TIMP1, α-SMA), inflammatory (TNF-α, IL-1α, MCP-1, CD68, F4/80, NLRP3) and oxidative stress marker (CYP2E1, Nqo1) genes were up-regulated after the LPD period (Figs 6 and 7).