This is in keeping with the general attitude of Italian oncologists: in a recent survey, aimed to investigate the approach of Italian oncologists and breast surgeons dealing with BC to fertility issues, 65% of panelists declared to use concomitant administration of GnRH analogs and chemotherapy regularly in their common clinical practice.21 This attitude might be influenced by the fact that the PROMISE trial, a large randomized trial concerning the use of GnRH analogs in this setting, was conducted in Italy.22 Moreover, this option is also recommended by national oncological guidelines.23 Here, GNRH1 is linked to breast cancer.