To model and study the consequences of the reduced expression of FOXO in NP, AF, and EP of degenerated IVD (Alvarez‐Garcia, Matsuzaki, Olmer, Masuda, et al., 2017), we generated mice with deletion of FOXO1, 3, and 4 in IVD tissues under the Col2a1 promoter (Col2a1‐Cre+/−; Foxo1fl/fl; Foxo3fl/fl; Foxo4fl/fl, herein referred as to Col2a1Cre‐FOXO KO). This evidence concerns the gene COL2A1 and atrial fibrillation.