MAPT and Alzheimer disease: Although the majority of inflammation in AD is attributed to glia dysfunction, especially in microglia and astrocytes, systemic inflammation shows a strong association with AD, as shown by an interesting experiment: Under systemic immune challenge by the viral mimic polyriboinosinic–polyribocytidilic acid, mice show sporadic AD phenotypes including Aβ plaques and altered Tau phosphorylation (Krstic et al., 2012).