62 It has been reported that systemic injection of IL‐12 into the LLC tumour‐bearing mice significantly reduces IL‐10 and TGF‐β expression in TAM and concomitantly increases expression IL‐6 and TNF‐α. 63 These results therefore collectively suggest that IL‐12 from CAR‐T cells reprogram macrophages recruited into the tumours to be tumoricidal cells that co‐operate with CAR‐T cells for elimination of cancer cells (Fig. 4b). This evidence concerns the gene TNF and neoplasm.