For example, injection of tumour lysate‐pulsed DC (DC‐based vaccination) prolongs survival of mice that have been orthotopically injected with syngeneic mesothelioma cells, and this therapeutic effect is further enhanced by DC‐based vaccination in combination with injection of PLX3397, a CSF1R inhibitor that depletes macrophages.40 Depletion of TAM also enhances the efficacy of therapeutic vaccination with strong adjuvants. This evidence concerns the gene CSF1R and neoplasm.