It is also reported that depletion of TAM enhances CD8+ T‐cell‐mediated antitumour immunity under treatment with chemotherapy in a mouse model of breast cancer.19 In addition, results from other mouse models of breast cancer indicate that physical contact of TAM with tumour‐infiltrating CD8+ T cells suppresses full activation of T cells or their access to the tumour cells.20, 21 Therefore, TAM has been suggested as one of the important therapeutic targets to enhance the efficacy of immunotherapy.22 This evidence concerns the gene CD8A and neoplasm.