Furthermore, knock-down of FOXC2 in combination with Etv2 has been shown to disrupt vascular development in the zebrafish (De Val et al., 2008) and mouse embryo compound mutants for FOXC1 and FOXC2 display arteriovenous malformations (Seo et al., 2006). This evidence concerns the gene FOXC2 and arteriovenous hemangioma/malformation.