During inflammation, IL-6 regulates the response of certain liver-specific transcription factors.7 In addition, IL-6 is a positive regulator of growth, and IL-1, IL-3, and IL-6 play a role in the proliferation, differentiation, and apoptosis of myeloid cells.8 The role of this proinflammatory cytokine in the activation and differentiation of cytotoxic T cells and NK cells is well documented; based on this activity, IL-6 pathway is being used in cancer treatment.8, 9 The IL-6 is a circular cytokine and its role on carcinogenesis in various hematological and solid tumors is clearly documented. This evidence concerns the gene IL6 and cancer.