Univariate analysis identified the significant factors contributing to ineffective drainage as the pre- endoscopic retrograde cholangiopancreatography (ERCP) serum total bilirubin level (P = 0.0075), pre-ERCP serum albumin level (P = 0.042), comorbid liver cirrhosis (P = 0.010), drained liver volume (P = 0.0010), and single stenting (P = 0.022). The gene discussed is ALB; the disease is cirrhosis of liver.